This DNA Fingerprinting Simulated Crime Scene Activity is a great way to begin your unit on the structure, function and processes of DNA in order to elicit student interest in learning about the DNA molecule! I introduce this crime scene situation on the first day of studying DNA then do a series of lessons on DNA structure and replication, all while the crime scene is set up in the classroom to keep my students engaged. The last day of the week, we do this fingerprinting activity to determine t